Brain cell damage caused by Aβ oligomers encompasses all major aspects of AD neuropathology [189], including oxidative stress, disruption of Ca2+ homeostasis, mitochondrial dysfunction, disturbed brain plasticity, aberrant tau phosphorylation, selective neuron death, neuroinflammation, inhibition of axonal transport, receptor redistribution, and insulin resistance. This evidence concerns the gene MAPT and Alzheimer disease.