MiR-140 downregulates OGN, resulting in activation of the Wnt signaling pathway and further modulating the expression of genes associated with the progression of pulmonary fibrosis in mouse fibroblasts, including transforming growth factor beta (TGF-β1), TNF-α and CTGF included (Figure 2) [25]. The gene discussed is TNF; the disease is pulmonary fibrosis.