Last but not least, the results of RT-qPCR revealed that the expressions of CTSS and FABP6 in BLCA tissues were significantly lower than those in adjacent normal tissues, and the expressions of NRP2, PDGFRB, S100A7, S100A8, S100A9, and S100A10 in BLCA tissues were significantly higher than those in adjacent normal tissues. The gene discussed is S100A8; the disease is bladder transitional cell carcinoma.