PROX1 and lymphedema: No significant changes in the expression patterns were observed for most of the common lymphatic markers—namely, PDPN, PROX-1, VEGF-A and VEGF-C—but we detected a 0.489-fold expression decrease in LYVE-1 (p = 0.024) and a 0.379-fold expression decrease in VEGF-D (p = 0.021) in the edematous lymphedema tissue compared to the healthy control (Figure 3D,E).