CD4 and lymphedema: A significant increase in CD4+ cells in the edematous lymphedema tissue versus the control was noted (p = 0.028) (healthy control [C]: 10.5 ± 5.8 cells/field versus non-lymphedematous tissue [C(LE)] 16.4 ± 8.8 cells/field (C vs. (C(LE) p = 0.089) and lymphedematous tissue [LE] 18.3 ± 6.9 cells/field), while the number of CD4+ cells was found to be comparable between the non-lymphedematous and lymphedematous tissue of the lymphedema patients (Figure 4A–C).