FUS and TPD-43 (TARDBP), marker and risk proteins linked to FTD that accumulate in the frontal and temporal lobes, were evaluated, as well as risk proteins that overlap between FTD and ALS including SQSTM1, VCP, TBK1, CHCHD10, C9orf72, and progranulin (GRN) [23,24]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.