TGM3 and amyotrophic lateral sclerosis: Based on its accuracy of CaMBP detection (~80%) and the significance of multiple binding domains mentioned above, this would suggest the following proteins as priority candidates for further investigation: PD (PINK1, LRRK2), LBD (TMEM175, GBA), ALS/FTD (TDP43, TBK1), and HD (Huntingtin, TGM2, TGM3) [29,65].