BACE1 and Alzheimer disease: In fact, calcium dysregulation (calcium hypothesis) that characterises AD affects the function of multiple critical, experimentally validated calmodulin binding proteins (calmodulin hypothesis) that are central to every stage of the disease (e.g., AβPP1, BACE1, ADAM10, PSEN-1, Aβ, NMDAR, PMCA, RyR2, ABCA1, BIN1, Ng, CaMKII, PP2B, Tau, cdk25, and others) [6,7,8,9,10].