The analyses here have shown that many key marker and risk proteins for HD (Huntingtin, TGM1, TGM2), PD (α-synuclein, PINK1, LRR2, PARK7), LBD (TMEM175, GBA), and ALS/FTD (TDP-43, SQSTM1, FUS, TBK1, C9orf72) all possess identifiable CaMBPs each with one or more binding motifs. Here, TGM2 is linked to amyotrophic lateral sclerosis.