It is well known that RPE cells could secrete lipoprotein-like particles containing apolipoprotein E (ApoE), A (ApoA), and B (ApoB) on the basal side of the epithelium, and the homeostasis of cholesterol is dysregulated in the RPE and adjacent Bruch’s membrane of AMD [34]. The gene discussed is APOE; the disease is age-related macular degeneration.