KL and neuroblastoma: Since research has recently proven that Klotho overexpression prevents ER stress-induced IRE1 response in senescent monocytes [89] and human renal epithelial HK-2, alveolar epithelial A549, HEK293, and SH-SH-SY5Y neuroblastoma cells [22], it would be reasonable to hypothesize that the current resistance training protocol did not promote an increase in Klotho expression to avoid a lower IRE1 response in the elderly.