To investigate the potential physiological role of STK10 in the anti-tumor immune response, we performed an integrative analysis of the influence of Stk10 knockout in the host on tumor growth and the components of the tumor microenvironment, by using a global Stk10 knockout mouse model and a syngeneic RM-1 murine prostate tumor cell line on the C57BL/6J background. Here, STK10 is linked to prostate neoplasm.