IFIH1 and diabetes mellitus: Experiments in EMCV-resistant C57/B6 mice demonstrated that a deficiency of MDA-5 or TLR-3 leads to the development of diabetes, suggesting that attenuated activity of these molecules, especially TLR3, may lead to blunted type1 IFN response, uncontrolled virus replication, and diabetes during pancreatic β-cell tropic virus infection [127].