Additionally, the MM BM microenvironment is enriched for coinhibitory molecules (e.g., PDL1 on MM cells, Galectin-3 and HLA-DR on MM cells, Galectin-9 in the MM BM plasma; and corresponding immune checkpoint receptors PD1, LAG3, and TIM3 on T cells) [111,112,113,114,115,116,117,118]. This evidence concerns the gene PDCD1 and Miyoshi myopathy.