Durability of BiTEs in MM is still under investigation but preclinical studies show rapid relapse after treatment discontinuation in de novo VK*MYC mice (model of NDMM) and transient responses with relapse occurring within 3 weeks of treatment in the more aggressive transplantable VK12598 syngeneic VK*MYC model [164]. Here, MYC is linked to Miyoshi myopathy.