For example, It allows for incorporation affected relatives with pancreatic and prostate cancer in addition to breast and ovarian and provides a mutation carrier likelihood for five BC risk genes (BRCA1, BRCA2, PALB2, ATM, CHEK2), and three ovarian cancer risk genes (RAD51C, RAD51D, BRIP1) compared to BRCA1 and BRCA2 only with IBISv8 ([26]). This evidence concerns the gene BRCA1 and breast cancer.