However, observations from many mouse models highlighted the inability of KRAS mutation solely to result in PDAC, as the development of PDAC was observed in only 7% of the mice; additionally, KRAS mutations were observed in healthy populations, suggesting the involvement of other factors, in addition to KRAS mutation, to induce PC [35,42,43,44,45,46,47,48,49,50,51]. This evidence concerns the gene KRAS and pachyonychia congenita.