CE-EUS appears to be an effective modality to detect PC, with superior outcomes to CT scan and MRI, and may be utilized for screening in first-degree relatives of patients with PC from familial syndromes, carriers of p16 or BRCA2 mutations with an affected first-degree relative, patients with Peutz–Jeghers and Lynch syndrome, and an affected first-degree relative with PC. Here, BRCA2 is linked to pachyonychia congenita.