GSEA showed significant enrichment in pathways such as mitotic prometaphase, kinesins, homologous DNA pairing, and strand exchange; MET activates the PTK2 signaling pathway, G1 to S cell cycle control, Aurora B pathway, ncRNAs involved in WNT signaling pathway, hepatitis C, and ncRNAs involved in STAT3 signaling pathway) in the high POGK gene expression phenotype in HCC in this study. This evidence concerns the gene POGK and hepatitis C virus infection.