A negative correlation was found between POGK expression and the abundance of gamma delta T cells (Tgd), T cells, natural killer (NK) CD56 dim cells, CD8+ T cells, neutrophils, regulatory T cells (TReg), plasmacytoid pre-dendritic cells (pDC), dendritic cells (DC), cytotoxic cells, while a positive correlation was found with the abundance of helper T2 (Th2) cells, T helper cells, NK CD56 bright cells, central memory T cells (Tcm), follicular helper T cells (TFH) in the HCC microenvironment (ps < 0.05) (Table 5 and Figure 8A–G). The gene discussed is CD8A; the disease is hepatocellular carcinoma.