SORT1 is another gene enriched in HIF-2 amplified UC tumors that are likely to be involved in allowing cancer cells to evade the immune system, given previously reported negative correlation with the infiltration levels of DCs, cytotoxic T cells, NK CD56dim cells, Tgd, and pDCs, as well as a positive correlation with immune evasion checkpoints including PDCD1, CD274, and CTLA-4 [28]. This evidence concerns the gene CTLA4 and cancer.