Second, by using the largest-to-date cohort of muscle-invasive UC this study revealed a distinct molecular and clinical profile in a subset of patients carrying somatic alterations in HIF-2/EPAS1.While these occur in nearly one-tenth of patients/tumors, they are associated with more aggressive histopathological features including higher T stage, presence of adenopathy, and high-grade disease. The gene discussed is EPAS1; the disease is lymphatic system disorder.