Recent studies have shown that naringenin, in addition to its effect on apoptosis, also has an inhibitory effect on proliferation (inhibits the phosphorylation of ERK1/2—extracellular signal-regulated kinase 1/2 and JNK—Jun N-terminal kinase) and angiogenesis (inhibits the expression of Tie2—tyrosine-protein kinase receptor-2 and enhances the expression of Ang2—angiopoietin-2) in murine and human melanoma cells (B16F10 and SK-MEL-28 cell lines, respectively) [43]. The gene discussed is ANGPT2; the disease is melanoma.