HMGCR and Hypercholesterolemia: This statin blocks 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prevents the conversion of mevalonate into cholesterol, being the most frequently used drug in the treatment of hypercholesterolemia to reduce the risk of cardiovascular diseases and to manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver [108].