The biological effects of MMP-1 include migration of keratinocytes, re-epithelialization, cell migration, platelet aggregation, increasing the bioavailability of insulin-like growth factors-1 (IGF-1), cell proliferation, pro-inflammatory effect, and poly(ADP-ribose) polymerase-1 (PARP-1) activation in cancer progression [11]. The gene discussed is IGF1; the disease is cancer.