Cellular injury in ischemic stroke causes the release of damage-associated molecular patterns (DAMPs) that activate microglia, leading to the secretion of pro-inflammatory cytokines such as interleukin (IL)-1β, tumor necrosis factor-alpha (TNF-α), or Il-6 within minutes after the onset of acute oxygen and glucose deprivation [11], as well as astrocytes, which proliferate rapidly and secrete pro-inflammatory cytokines, chemokines, and metalloproteinases [57]. This evidence concerns the gene TNF and ischemic stroke.