As even accurate weight gain may be difficult to measure routinely in preterm infants, recently, DIGIROP using GA at birth, sex, standardized birth weight and age at the first sign of ROP was developed to predict the risk for severe ROP and shows high predicative ability in a contemporary Swedish cohort without using either IGF-1 or weight gain (Pivodic et al., 2022). The gene discussed is IGF1; the disease is retinopathy of prematurity.