Typically, HGPS patients show a single-basepair substitution (c.1824C > T, p.Gly608Gly) within exon 11 of LMNA.2,3 Amutant protein called progerin is generated as a consequence of themutation, which leads 150 nucleotides in lamin A to be deleted. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.