The incidence of immune-complex GN associated with ICIs therapy was also high, with 10 related cases consisting of 6 cases of IgAN [11,20,35,36,38], one Lupus Nephritis [13], one immune mediated glomerulonephropathy with IgA and C3 deposits [15], one immune mediated glomerulonephropathy with only IgM deposits [25], and one immune mediated glomerulonephropathy with deposits of C3 (2+-3+) and IgG (1+) [23]. This evidence concerns the gene C3 and lupus nephritis.