To identify reliable and effective biomarkers for PaCa prognosis, we first constructed a prognostic risk model to screen previously unidentified immune-related lncRNAs, including LINC02325, FNDC1-AS1, ZEB2-AS1 and TEX26-AS1 GO and KEGG functional enrichment analyses revealed that these four IRlncRNAs and coexpressed mRNAs were significantly enriched in various immune-related biological processes. Here, ZEB2 is linked to permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.