Although the immunosuppressive state as a distinct biologic feature of pancreatic cancer was observed in many patients (42) and the circulating levels of IL-6, IL-18 and TGF-beta2 in the sera have also been reported to reflect the survival probabilities of patients with PaCa (43), our present data outlined a potentially added clinical value, as LINC02325, FNDC1-AS1, and ZEB2-AS1 may be prognostic factors in patients with pancreatic cancer. This evidence concerns the gene IL18 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.