Exposure of monocytes to TNF induces a wave of calcium oscillations and subsequent induction and activation of NFATc1 that enhances osteoclastogenesis in response to RANKL (22) Thus, to determine whether the absence of DC-STAMP attenuates bone resorption during arthritis development, we evaluated bone density in the growth plate of tibias and femurs from 5-month-old Tg(hTNF) and Dcstamp-/-;Tg(hTNF) female mice, along with Dcstamp-/- and WT controls. The gene discussed is TNFSF11; the disease is arthritic joint disease.