Measurements showed increased C1-INH complex levels in COVID-19 patients when compared to healthy controls, with a mean concentration of 2407 ± 1283 ng/mL C1s/C1-INH complex (Mann-Whitney U test: p<0.0001, Figure 9A) and 51.5 (33.5-76.1) ng/mL MASP-1/C1-INH complex (Mann-Whitney U test: p<0.0001, Figure 9B). This evidence concerns the gene C1S and COVID-19.