CD160 expression activates prosurvival signaling through the upregulation of PI3K/Akt signaling pathway and increases the secretion of cytokines, mainly the proinflammatory cytokine IL-6 (46); this interleukin activates signal transducer and activator of transcription 3 (STAT3) and NF-κB, which regulate the expression of several genes implicated in CLL cell proliferation and survival (106). The gene discussed is STAT3; the disease is B-cell chronic lymphocytic leukemia.