(11), we found the Treg cell and CD8+T/CD4+T cell ratio especially memory T cells in thyroid tissues significantly higher than peripheral blood of MNG patients, whereas that in NK cells was the opposite (Figures 1E–J), indicating the activation of antigen-specific naïve T cells in thyroid tissue and migration of memory T cells through blood and home to inflamed tissue (35). The gene discussed is CD8A; the disease is toxic multinodular goitre.