This results in translation of a full-length protein with a single amino acid change, but probably active, protein.20, 21, 22, 23 We recently reported that treatment with different TRIDs has a positive effect on ciliogenesis, cilia length, and localization of FAM161A along microtubules of ciliated fibroblast cells that originated from FAM161A-RP patients harboring the common nonsense pathogenic variant in a homozygous state.24 The gene discussed is FAM161A; the disease is retinitis pigmentosa 1.