Currently, TERT and TERC gene mutations are considered susceptibility markers of fibrotic lung disease (Armanios et al., 2007).73 patients with TERT and TR mutations from the Vanderbilt Familial Pulmonary fibrosis Registry were screened, and 6 patients had TERT or TR heterozygous mutations (Petrovski et al., 2017), TERT mutations were also found in 5% of sporadic IPF case studies. This evidence concerns the gene TERC and idiopathic interstitial pneumonia.