Ubiquitination is a cascade of enzyme reactions catalyzed by ubiquitin activase (E1), ubiquitin-binding enzyme (E2), and ubiquitin ligase (E3) (Popovic et al., 2014).Ubiquitin E3 ligase and DUBs regulate pulmonary fibrosis by regulating TGF-β-dependent and independent pathways (Jaitovich et al., 2008; Li et al., 2018). Here, TGFB1 is linked to pulmonary fibrosis.