AKT1 and glioblastoma: These data are consistent with previous studies, where ectopic expression of Lrig1 opposed EGFRvIII driven proliferation, survival and invasion in GBM cells (Stutz et al., 2008), and RNAi of Lrig1 promoted aggressiveness via EGFR/Akt/c-myc activation (Xie et al., 2013).