ADRA2A and type 2 diabetes mellitus: We found that the wound-healing rate, the growth of hair follicles around the wound, and the expression of growth factors were increased while inflammatory factors decreased after Adra2a knocked-down T2D ASC transplantation in the in vivo experiments, and the results further demonstrated that Adra2a knocked-down T2D ASCs showed increased cutaneous wound-healing capabilities compared to untreated T2D ASCs.