TNF and rheumatoid arthritis: prepared a dexamethasone (DMT)-loaded HA-Tyr-based hydrogel to optimize the therapeutic effect on collagen-induced rheumatoid arthritis (RA) by reducing interleukin-6 (IL-6), prostaglandin E2, and the levels of four cytokines, including IL-8, IL-1β, tumor necrosis factor-α (TNF-α), and CD 14 [120].