The Th1 response is prevalent in active TAO or GD; and chemokine (C-X-C motif) receptor 3 (CXCR3) and Th1 chemokine (C-X-C motif) ligand 9, 10, and 11 (CXCL9, CXCL10, and CXCL11) are crucial in this process [139]. This evidence concerns the gene CXCL9 and thromboangiitis obliterans.