FOS and amyotrophic lateral sclerosis: Previous studies show that c-Fos and other members of the Fos family can induce neuronal death in a p53-dependent manner (Preston et al., 1996; Hafezi et al., 1997; Chen et al., 2015), modulate NMJ function in Drosophila (Sanyal et al., 2003) and induce motor axon branching in human ALS motor neurons (Akiyama et al., 2019).