Transcriptional profiling of SMA motor neurons identified several upregulated p53 effectors (Simon et al., 2017), of which most are associated with suppression of apoptosis, tumor growth, oxidative stress response or cell cycle arrest, but two others, perp and c-fos, have been linked to cell death (Attardi et al., 2000; Seoane et al., 2002; Ihrie et al., 2003; Hartland et al., 2009; Sareen et al., 2012; Miyake et al., 2015; Murray et al., 2015; Simon et al., 2017; Han et al., 2018). The gene discussed is TP53; the disease is neoplasm.