There is mounting evidence that the activation of the tumor suppressor p53 pathway contributes to neuronal death in PD, AD, HD, and motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) (Zhang et al., 2002; Chang et al., 2012; Qi et al., 2016; Simon et al., 2017; Vogt et al., 2018; Buettner et al., 2021; Maor-Nof et al., 2021). The gene discussed is TP53; the disease is Alzheimer disease.