Previous studies show that c-Fos and other members of the Fos family can induce neuronal death in a p53-dependent manner (Preston et al., 1996; Hafezi et al., 1997; Chen et al., 2015), modulate NMJ function in Drosophila (Sanyal et al., 2003) and induce motor axon branching in human ALS motor neurons (Akiyama et al., 2019). The gene discussed is TP53; the disease is amyotrophic lateral sclerosis.