MALAT1 and neoplasm: A 1,000-fold knockdown of MALAT1 in human lung cancer cells via zinc finger nuclease technology impairs cancer cell migration (Coros et al., 2008; Gutschner et al., 2013), and blocking the lncRNA MALAT1 pathway regulates EMT and combats tumor metastasis (Masuzawa and Kitazawa, 2021).