It has been empirically demonstrated that lncRNA prostate cancer-associated transcript 29 (PCAT29) inhibits the miRNA-221-mediated RASAL1/ERK1/2 signaling pathway downstream of transforming growth factor β1 (TGF-β1) in lung fibroblasts, thus suppressing certain proinflammatory cytokines associated with lung fibrosis, such as N4bp2 and Plxna4, and ultimately slowing the progression of pulmonary fibrosis (Liu et al., 2018). The gene discussed is TGFB1; the disease is pulmonary fibrosis.