Although at this time, we were unable to provide evidence on the association between this missense substitution and CP, we are interested in the position of amino acid 224 within the coding region of exon 3 (Supplementary Figure S8), a region critical for intracellular trafficking of CAPS2, which was previously identified as deleted in patients with autism (Sadakata et al., 2007b). The gene discussed is CAPS2; the disease is autism.