In addition, Cadps2 KO mice exhibited pathophysiological phenotypes including a progressive loss of acini, alternatively increasing adipocytes and interstitial cells, leading to pancreatic acinar cell atrophy, fibrosis, and intense focal inflammation, which was reminiscent of that observed in a caerulein-induced pancreatitis mouse model (Nagashio et al., 2004). The gene discussed is CADPS2; the disease is pancreatitis.