NLRP3 and acute pancreatitis: Previous studies showed that the NLRP3 inflammasome is activated in pancreatic acinar cells of an acute pancreatitis mouse model and mediates pancreatic acinar cell death responses and systemic inflammation (Gao et al., 2021), and that the activity of NOD-like receptor NOD1 has a role in pancreatic inflammation in a CP mouse model (Watanabe et al., 2016).