Acinar cell degeneration, fibrosis, and inflammation observed in the exocrine pancreas of Cadps2-KO mice were progressive but appeared relatively mild compared to those in chemically induced acute pancreatitis models and certain genetically-modified pancreatitis mouse models, many of which show fulminant symptoms (Merry and Petrov, 2018). The gene discussed is CADPS2; the disease is acute pancreatitis.