Early predictors that have been reported are as follows: C-reactive protein/albumin ratio, serum albumin concentration, interleukin (IL) 6 and coagulation function at NEC diagnosis, trends in C-reactive protein and lactate within 72 h of NEC diagnosis, IL-8 and IL-10 within 72 h of life (infants born less than 1500 g), and hyponatremia and/or the sudden decrease in plasma sodium at the onset of NEC (2, 16, 31–34). This evidence concerns the gene CRP and Hyponatremia.