Cytomegalovirus IgM and IgG antibodies were found in 2.72% and 36.73% of the children, and EB virus IgM and IgG antibodies were found in 3.40% and 41.50% of the children, respectively, indicating that viral infection may be a pathogenic factor of profound SSNHL in children, similar to that reported by Pitaro et al. (14). The gene discussed is CD40LG; the disease is viral infectious disease.