Interestingly, relative to healthy donor controls, the percentage of NKG2A+CD57- (immature-like) NK cells were significantly increased (P=0.0242), whereas NKG2A-CD57+ (mature) NK cells were significantly decreased (P=0.0474), suggesting that patients with ALL exhibit defects in NK cell terminal differentiation (Figures 5A, B). The gene discussed is B3GAT1; the disease is acute lymphoblastic leukemia.