When the logistic regression analysis was adjusted by sex, age and infection, we found that a decrease in the percentage of DNAM-1+NK cells, 2B4+NK cells, NTBA+NK cells, and SLAMF7+ NK cells, as well as a decrease in their expression levels on NK cells, were associated with lymphoblastic acute leukemia during childhood at the moment of ALL diagnosis (Table 2). The gene discussed is CD244; the disease is acute lymphoblastic leukemia.