For example, it has been documented that ERβ downregulation prevents breast cancer cell migration through tyrosine kinase receptor [epidermal growth factor receptor (EGFR)/insulin-like growth factor-I receptor (IGF-IR)] and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways [reviewed by (51)]. The gene discussed is ESR2; the disease is breast cancer.