This is accomplished by inducing (i) the activation of signaling proteins (c-Src, FAK, paxillin, ERK and protein kinase B phosphorylation) related with cell migration (76); (ii) binding to a G protein coupled to ER (GPR30); this GPR30/E2 complex triggers a protein kinase (PRKACB) to phosphorylate and inactivate the aquaporin AQP2, which is involved in cancer cell migration (77). The gene discussed is PRKACB; the disease is cancer.