Currently, copper has been found to play an important role in the high-affinity copper transporter (CTR-1) (32), LOX (33), hypoxia-inducible factor (HIF-1α) (34), antioxidant protein-1(ATOX-1) (35, 36), RAS-RAF-MEK-ERK signaling pathway (37) (38, 39) and PD-L1 (40), which are associated with tumorigenesis, adaptation to hypoxic environment (41), tumor extracellular matrix construction(ECM), neovascularization, epithelial to mesenchymal tissue transition (EMT) and tumor metastasis. This evidence concerns the gene CD274 and neoplasm.