Tumor immune escape is a protective mechanism by which tumor cells protect themselves from the immune system, mainly through the binding of PD-L1, which is overexpressed by tumor cells, to PD-1, which is expressed by lymphocytes, and thereby exerting a negative regulatory effect on T lymphocytes and resulting in diminished cytokine production and cytotoxic effects of immune cells on tumor cells. This evidence concerns the gene CD274 and neoplasm.