FGF2 and neoplasm: Many tumors stimulate tumor growth through neovascularization (81), which is regulated by angiogenesis-stimulating factors (angiogenin, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and transforming growth factor β (TGFβ)), cytokines (IL-1, -6 and -8)) and angiogenesis-inhibiting factors (vasopressors and endothelial inhibitors) (3).