Next, we started with differentially expressed genes (DEGs) acquired from the comparison of immune and stromal component in BLCA samples, and found out that CXC chemokine ligand-12 (CXCL12) acted to be a potential biomarker and a promising modulator of TIME through its communicating with multiple TICs,. The gene discussed is CXCL12; the disease is bladder transitional cell carcinoma.