In addition, hypomethylation of TSTD1 promoter was observed obviously in breast tumor tissues from Asian, Caucasian and Black/African American TCGA cohort compare with breast tumor tissues from Taiwanese cohort (Figure 1C), Further analysis of the methylation patterns of other cancer types indicated that TSTD1 promoter hypomethylation was observed in lung adenocarcinoma and lung squamous cell carcinoma (Figure 1C) but not in liver, colon, esophageal, rectal, and pancreatic cancers (Figure S2). The gene discussed is TSTD1; the disease is familial pancreatic carcinoma.