ENO2 and papillary renal cell carcinoma: Besides, Tang et al. [10] reported that kruppel-like factor 12, a transcription factor, could hamper the proliferation of bladder cancer through transcriptional inhibition of ENO2. Moreover, Sun et al. [11] found that overexpression of ENO2 might lead to the enhanced malignant behavior of cancer cells and a worse prognosis, associated with increased glycolysis in papillary renal cell carcinoma.