TNF and atherosclerosis: KEGG enriched 30 signaling pathways, among which the important signaling pathways included the citrate cycle (TCA cycle), ascorbate and aldarate metabolism, drug metabolism, TGF-beta signaling pathway, tyrosine metabolism, sphingolipid metabolism, fatty acid degradation, pyruvate metabolism, TNF signaling pathway, relaxin signaling pathway, and fluid shear stress and atherosclerosis.