The genotype analysis of the lnc-ZNF33B-2:1polymorphism revealed a remarkable difference in the carriers of the rs579501 genotypes exhibiting the CC allele (adjusted odds ratio = 2.026, 95% CI = 1.156–3.551, p = 0.0136), suggesting that rs579501 CC genotypes increased sepsis susceptibility. This evidence concerns the gene ZNF33B and Sepsis.