Compared with paracancerous nontumor tissues, the expression levels of TLR3 were significantly elevated in GBM, KIRC, LGG, PAAD and STAD, while suppressed in TGCT, COAD, BLCA, KICH, BRCA, HNSC, LUAD, PRAD, READ, KIRP, LIHC, THCA, LUSC, STAD and UCEC. This evidence concerns the gene TLR3 and glioblastoma.