For example, high expression of TLR3 prolonged the survival time of patients with non-small-cell lung cancer by inducing apoptosis of cancer cells (Bianchi et al., 2020), but high expression of TLR3 could promote the migration of breast cancer cells by increasing the expression of E-cadherin (Bondhopadhyay et al., 2015). The gene discussed is CDH1; the disease is breast carcinoma.