CD8A and neoplasm: In KIRC patients, B cells infiltration prolonged tumor-specific survival (Stenzel et al., 2020), CD8+T cells infiltration prolonged patients’ OS outcome (Zhang et al., 2019), elevated neutrophils abundance was associated with favorable prognosis (Niu et al., 2021), what’s more, infiltration of dendritic cells and T cells and elevated adaptive immune response could effectively inhibit tumor recurrence and metastasis [(Lim et al., 2007); (Ghatalia et al., 2019)].