Our results based on 349 patients with non-severe COVID-19 Omicron variant enrolled in designated hospital revealed that (1) the incidence of hyposmia after Omicron infection was relatively low and the short-term recovery rate was quite high; (2) patients with hyposmia had more associated clinical symptoms and increased proportions of both upper and lower respiratory tract involvements, contributing to a longer duration of hospitalization;(3) serum IL-6 and TNF-α levels were not related to hyposmia occurrence, severity or recovery. Here, IL6 is linked to COVID-19.