For instance, lncRNA inducing major histocompatibility complex-I and tumor immunogenicity, as a tumor immunogenic lncRNA (LIMIT), can induce the expression of major histocompatibility complex-I via targeting the LIMIT–GBP–HSF1 axis, promoting T-cell-mediated tumor immune response and enhancing immunotherapy efficacy [13]. Here, HSF1 is linked to neoplasm.