Similarly, Liang et al. and group discovered the effect of berberine in 3xTg AD (triple-transgenic AD) mice and observed that protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α signal pathway was diminished, further declining Aβ growth and thus improving neuronal functions by mitigating ER and oxidative stress (Liang et al., 2021). This evidence concerns the gene EIF2A and Alzheimer disease.