Some of the distinguishing features of these diseases are the accumulation of polyglutamine protein aggregates in HD and other repeat CAG-polyglutamine diseases, the intracellular storage of Aβ-synuclein in PD, and the inclusion of TAR DNA-binding protein (TDP)-43 transactive response in ALS, frontotemporal dementia, and other related disorders (Arnold et al., 2013; Toyoshima and Takahashi, 2014). Here, TARDBP is linked to Huntington disease.