We have repeatedly reported that a single exposure to 0.1N hydrochloric acid leads to pulmonary fibrosis in mice, which is reflected in upregulation of ECM, and have considered HSP90 as a potential therapeutic target (Marinova et al., 2019; Solopov et al., 2020; Colunga Biancatelli et al., 2021a; Solopov et al., 2021). This evidence concerns the gene HSP90AA1 and pulmonary fibrosis.