As we previously reported, HSP90 inhibitors AUY-922 (Marinova et al., 2020) and AT-13383 (Colunga Biancatelli et al., 2022a) significantly downregulate the overexpression of collagen, fibronectin and elastin expression in mice with HCl-induced pulmonary fibrosis. The gene discussed is HSP90AA1; the disease is pulmonary fibrosis.